Manganese deficiency could mean that calcium cannot stick to bone and cause osteoporosis. This can happen in the presence of sufficient calcium in the body. Manganese is extracted from bone when there are unmet needs for it in the brain, kidney, liver, and pancreas. Manganese deficiency could also play a role in Alzheimer's disease, Parkinson's disease, and senile dementia. When compared to people with osteoarthritis, people with osteoporosis have a far higher incidence of senile dementia.
