According to Joslin Clinic Studies published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology, high levels of insulin in themselves do not cause arteriosclerosis. Without other factors such as high blood pressure, high cholesterol, or type 2 diabetes, high levels of insulin do not cause arteriosclerosis. There must be insulin resistance in endothelial cells (which line blood vessel walls) to increase susceptibility to arteriosclerosis. To prevent arteriosclerosis we'll need to focus on improving insulin signaling in vascular endothelial cells rather than blocking the action of insulin in these cells.
This data also suggests that it is possible to treat type 2 diabetics with insulin if they cannot be controlled by lifestyle measures or oral hypoglycemic drugs.
