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  Theories about the cause of cancer are many but the answers are not clear. Aneuploidy is an imbalance of the number of chromosomes, In cancer they usually range between 60-90 chromosomes rather than 46. No two cancers are the same. Normal cells do not de-differentiate, they progress in an abnormal way. Gene mutations are too small to cause cancer.                

BPH begins at age 50 and may lead to urinary obstruction. Differentiation from prostate cancer can be difficult. The use of the PSA test is controversial