The CDC recently reported that there is widespread and increasing medication use among pregnant women even though there is insufficient information on the risks and safety of the vast majority of medications, whether OTC or prescription. About 3/4 of all pregnant women use at least one medication during the first three months of their pregnancy. Over the past 30 years, the use of 4 or more medications during the first trimester tripled. The use of antidepressants is one example even though there are well known congenital abnormalities associated with their use. Both MDs and patients need to be cognizant of this problem.