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NSAIDs cause ulcers and proton pump inhibitors help prevent them. Why not combine them? Novel thought, but how wise is this? A clinical trial was done over a 30 day period that showed that GI bleeding was substantially reduced by this combination. There are many problems with this kind of reasoning. First, most people aren't on NSAIDs for only 30 days...

New drugs are problematic because they are not fully tested. Post marketing studies should be required. It is wiser to use old time-tested drugs because they've been around for decades and we know their complications. Vioxx is an interesting example. Cox 1 and Cox 2 inhibitors are explained.