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Metal on metal hip prostheses are made of titanium, chromium, and cobalt. When they wear out they release chromium and cobalt into the local tissues, but also into the circulation. Metallosis can result and sometimes leads to tremendous inflammation. The orthopedic community does not yet accept this entity, yet 93,000 DePuy hip prostheses are being recalled....

  The cause of metal-on-metal hip implant related pain caused by cobalt, can be from both toxicity to or hypersensitivity. A study reported at the 2013 annual meeting of the American Academy of Orthopedic Surgeons evaluated patients with metal-on-metal hip replacements who returned to the hospital for revision surgery because of pain. They compared 50...