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Antidepressants, especially those in the SSRI category such as Zoloft, Prozac, Paxil, may not work in people also taking painkillers such as ibuprofen and aspirin. This combination leads to lowered serum levels of the antidepressant and less antidepressant effects. This is just one more example of how many potential complications there are to using SSRI antidepressants....