The story on whether or not intravenous vitamin C works has been ongoing for more than 40 years, when Linus Pauling began studing this treatment. The clinical trials that have been completed are controversial and have led to arguing. Studies on oral vitamin C show it does not work. However, intravenous treatment vitamin C leads to much higher levels of serum vitamin C and sets the stage for another story. NIH studies are now underway. The mechanism of action of IV vitamin C is reviewed.