NSAIDs have now been linked to an increased incidence of atrial fibrillation and flutter. The association was strongest for new users. The risk is increased by 40% for COX-1 inhibitors and 70% for COX-2 inhibitors such as Celebrex. This translates to 1 in 250 taking COX-1 drugs and 1 in 140 taking Celebrex. The risk is highest for the elderly, those with rheumatoid arthritis and chronic kidney disease. Other side effects of this class of drugs include heart attacks, strokes, ulcers, and kidney failure.