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These over the counter analgesics increase the risk for hypertension in 20-50%. Fluid retention is one mechanism. DTC ads lead to their overuse. There are many other side effects as well.        

New drugs are problematic because they are not fully tested. Post marketing studies should be required. It is wiser to use old time-tested drugs because they've been around for decades and we know their complications. Vioxx is an interesting example. Cox 1 and Cox 2 inhibitors are explained.

The effectiveness of NSAIDS for longterm pain is questionable according to new research. Chronic use of these drugs shows their effectiveness is close to that of a placebo. There are many alternatives to drugs for pain management that are more effective and far safer. More than 30,000 people die annually in the US from this class of drugs, which include Advil,...