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New drugs are the poorest tested and Americans are the guinea pigs for the first few years after release. Most new drugs have new side effects reported and 20% wind up off the market or with black box warnings. The FDA does not regulate Big Pharma and has a conflict of interest position with them

We are guinea pigs whenever a new drug comes onto the market. This is especially true for drugs that are "fast tracked" through the FDA. Post approval clinical trials are required in this setting by the FDA from big pharma, but often they are not done. Older drugs that have been on the market for decades are generally better tested and safer.