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  Use of proton pump inhibitors such as Prilosec, Nexium, Protonix, Aciphex and others were associated with a 320% increase in C. diff enterocolitis after just 30 days of treatment. PPIs block the absorption of calcium, magnesium, iron and B12 and increase the risk for osteoporosis, senile dementia, and cardiac rhythm disturbances as well.                  

NSAIDs cause ulcers and proton pump inhibitors help prevent them. Why not combine them? Novel thought, but how wise is this? A clinical trial was done over a 30 day period that showed that GI bleeding was substantially reduced by this combination. There are many problems with this kind of reasoning. First, most people aren't on NSAIDs for only 30 days...

Proton pump inhibitors (PPIs) such as Prilosec, Nexium, Protonix, and Aciphex have been available for about 20 years and each year about 15 million people use them and bring in $10 billion every year. PPIs are vastly overprescribed by MDs and because they are available over the counter, are overused by patients. The major known side effects of PPIs include...

  Four billion prescriptions were filled in the US in the year 2011 and at a cost of $227 billion according to the World Pharmaceutical Market Summary. The top five therapy classes of drugs were statins, antiulcerants, antidepressants, antipsychotics, and antihypertensives. The top five drugs sold were, Lipitor, Plavix, Nexium, Seretide, and Crestor....