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According to an article published in the April 2013 issue of the journal Internal Medicine, patients on SSRI antidepressants at the time of surgery have a 20% increased mortality, 9% increased risk for bleeding, and 22% increased risk for  readmission within a month of discharge from the hospital! This was based on a review of 530,000 surgical patients from...

  Combining SSRI antidepressants with aspirin or other NSAIDs can lead to a 42% increase risk for bleeding. SSRIs may inhibit the uptake and storage of serotonin by platelets. Low platelet serotonin leads to reduced platelet aggregation and a tendency to bleed. Considering that SSRIs have little evidence that they work better than placebo and that...