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  The cause of metal-on-metal hip implant related pain caused by cobalt, can be from both toxicity to or hypersensitivity. A study reported at the 2013 annual meeting of the American Academy of Orthopedic Surgeons evaluated patients with metal-on-metal hip replacements who returned to the hospital for revision surgery because of pain. They compared 50...

  Glucocorticoids such as Prednisone and Prednisolone can cause osteoporosis within 3-6 months of use and lead to fractures, especially vertebral fractures. Nearly 5% of women in the US are on these drugs for a variety of conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, vasculitis, and a myriad of skin disorders. The risk...