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The FDA is recommending that physicians restrict prescribing high-dose Zocor because of an increased risk of muscle damage that can lead to pain and also the release of large amounts of myoglobin from muscle from a process called rhabdomyolysis, which can lead to renal failure and death. They also warned that the use of several anti-fungal agents such as Sporonox,...

A meta-analysis showed that high dose statin therapy as primary prevention caused an increased risk for type 2 diabetes. The article published in JAMA goes on to say that treatment of 32,000 non-diabetics with 5 years high dose statin treatment caused 149 more cases of type 2 diabetes, but 416 fewer cardiovascular events.This is a very misleading journal article...